WOUNDCUR GEL - A Natural Wound Healing Preparation for Topical Wound Care

Dressing with Phosphorylase Kinase Inhibitors

Wound healing in adult skin, a complex process involving many cell types and processes such as epidermal, fibroblastic and endothelial cell proliferation, cell migration, matrix synthesis and wound contraction, almost invariably results in scar tissue formation and wound induration in adult skin. However, it is worth noting that wound healing in embryonic skin involves repair processes that results in essentially perfect regeneration of the damaged tissue (Martin P. Wound healing – aiming for perfect skin regeneration. Science 1997;276:75-81). 

Why Does Wound Healing Almost Always Result in Scarring?

Scarring is associated with inflammation, resulting in the secretion of inflammatory cytokines, and growth factors. It is believed that transforming growth factor-beta (TGFβ), which stimulates the conversion of fibroblasts into myofibroblasts, is predominantly responsible for scarring following injury such as burns and surgical trauma. Wound tension and infections, which increase the secretion of TGFβ, are also associated with increased scarring. It is of interest that embryos, with immature inflammatory cells, are incapable of producing TGFβ.

Injurious processes including burns and surgical trauma trigger wound healing processes by energizing transcription activators, such as nuclear factor kappa B (NF-kB). NF-kB is a family of related dimers, which bind to a common sequence on the DNA, the kB site. In the non-activated state these dimers (p50/p65) are located in the cytoplasm. When activated by injurious stimuli, the activated p50/p65 dimers translocate to the nucleus, where they bind to the DNA, resulting in the transcription of over 200 genes involved in the processes of wound healing.

Woundcur® Gel Synergizes as Adjunctive Therapy

The process of activating NF-kB dimers in the cytoplasm involves the removal of an inhibitory protein (IkBα) by phosphorylation of its kinase (IkBα) kinase. This is achieved through phosphorylation of IkBα kinase at its serine/threonine sites by phosphorylase kinase (PhK). 

Woundcur® Gel contains a proprietary preparation derived from Curcumin extract and other plant-based ingredients that provide a potent inhibitor of NF-kB activation, as a well as protection from re-injury of the wound. The gel dressing may be used as a topical agent combined with approved dressings for wound healing for ulcers, burns and surgical wounds*.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

For more information, please view research publications on Phosphorylase Kinase inhibition strategies for Wound Healing.